These videos should give you an idea of various guitar+amp combination & a few effects boxes (stomp boxes).
PLEASE NOTE; These are fairly low-quality videos recorded with an inexpensive "still" digital camera with video capabilities & and an inexpensive built-in mic. The camera is approximately 2006 technology.
Les Paul into a Vintage Marshall
"Historic Reissue" Gibson Les Paul with Holmes pickups into a 1968 Marshall "Plexi" (50watt) into an early 70s Marshall 4x12 cabinet with "Greenback" speakers.
Note that a "clean boost" pedal (MXR MicroAmp) is used part of the way through to overdrive the amp even further. A clean boost has no distortion of it's own, but boosts the guitar signal to send a hotter signal to the amp. Different amps tend to react differently to clean boosts. Early Marshalls match up well with most clean boosts.
Also, this is a great vintage Marshall video by someone else;
Stevie Ray Vaughn
This is probably the most recognized "Fender into a Fender" tone.
SRV of course has several "tones". This is similar to his basic tone. Overdriven but not fizzy.
The Stratocaster (80s Made in Japan) has Fralin Blues Specials pickups & strings are DR Blues 10s, going through a Marshall Blues Breaker pedal (a Tube Screamer is usually associated with SRV) into a reissue Fender Deluxe Reverb. Amp volume is 3, both treble & bass are about 3/4 of the way up.
This is my "at home" practice setup. Of course for larger live gigs a Super Reverb will also do the job!
Telecasters Can Rock!
For years I foolishly ignored Telecasters since I am a Blues-Rock guy and associated Telecaster with "Country Music". Boy was I wrong! This Tele clone with a hot bridge pickup is becoming my favorite guitar. And the bridge pickup can do a decent SRV or Hendrix.
The amp setup is simply a Deluxe Reverb & a first generation Marshall Blues Breaker pedal (black).
My "Marshall at Home" setup is simply a Deluxe Reverb & a first generation Marshall Blues Breaker pedal (black). No, it doesn't sound exactly like a Marshall, but it close enough for me at home playing at "low volume". The amp volume is on 3 with no distortion coming from the amp.
Just Got Paid using a Les Paul
Waitin' For The Bus using a Les Paul (not exactly my best effort)